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Package-Ref? Lung Cancer Reference Standard Package
| Package-Ref™ Lung Cancer Reference Standard Package | |||||
| Cat No. | CBP90022 | ||||
| Format | Genomic DNA | ||||
| Description | 包含6管標準品，作為參考品、質控品、精密度、檢測限 | ||||
| Panel-Ref™ gDNA Cocktail III Reference Standard | |||||
| Gene | AA Change | CDS Change | Exon | Cosmic ID | Expected AF |
| EFGR | p.E746_A750delELREA | c.2235_2249del15 GGAATTAAGAGAAGC>- | 19 | COSM6223 | 5% |
| EFGR | p.L858R | c.2573T>G | 21 | COSM6224 | 5% |
| EGFR | p.T790M | c.2369C>T | 20 | COSM6240 | 5% |
| EGFR | p.G719S | c.2155G>A | 18 | COSM6252 | 5% |
| BRAF | p.V600E | c.1799T>A | 15 | COSM476 | 內源突變 |
| KRAS | p.G12D | c.35G>A | 2 | COSM521 | 5% |
| KRAS | p.Q61H | c.183A>C | 3 | COSM554 | 內源突變 |
| PIK3CA | p.E545K | c.1633G>A | 10 | COSM763 | 5% |
| PIK3CA | p.H1047R | c.3140A>G | 20 | COSM775 | 內源突變 |
| EML4-ALK | E13-A20 | DNA Translocation | N/A | COSF408 | 5% |
| CCDC6-RET | E1-E12 | DNA Translocation | N/A | COSF1271 | 5% |
| ERBB2 | CNV | Amplication | N/A | N/A | CN=6 |
| MYC | CNV | Amplication | N/A | N/A | CN=10 |
| Panel-Ref™ gDNA Cocktail IV Reference Standard | |||||
| Gene | AA Change | CDS Change | Exon | Cosmic ID | Expected AF |
| EGFR | p.G719S | c.2155G>A | 18 | COSM6252 | 5% |
| BRAF | p.V600K | c.1798_1799GT>AA | 15 | COSV56057713 | 5% |
| PIK3CA | p.H1047R | c.3140A>G | 20 | COSM775 | 5% |
| KRAS | p.G13D | c.38G>A | 2 | COSM532 | 5% |
| NRAS | p.G12D | c.182A>G | 3 | COSM584 | 5% |
| BRCA2 | p.I2675Dfs*6 | c.8021dup | 18 | COSM2071519 | 5% |
| SLC34A2-ROS1 | E4-E32 | DNA Translocation | N/A | COSF1197 | 5% |
| EML4-ALK | E6-A20 | DNA Translocation | N/A | COSF408 | 5% |
| CCDC6-RET | E1-E12 | DNA Translocation | N/A | COSF1271 | 5% |
| MET | Exon 14 Skippig | c.3082+1G>T | N/A | COSM6108462 | 5% |
| ERBB2 | CNV | Amplication | N/A | N/A | CN=6 |
| MYC | CNV | Amplication | N/A | N/A | CN=7 |
| Panel-Ref ™ gDNA Cocktail V Reference Standard | |||||
| Gene | AA Change | CDS Change | Exon | Cosmic ID | Expected AF |
| EFGR | p.E746_A750delELREA | c.2235_2249del15 GGAATTAAGAGAAGC>- | 19 | COSM6223 | 3% |
| EFGR | p.L858R | c.2573T>G | 21 | COSM6224 | 3% |
| EGFR | p.T790M | c.2369C>T | 20 | COSM6240 | 3% |
| EGFR | p.G719S | c.2155G>A | 18 | COSM6252 | 3% |
| BRAF | p.V600E | c.1799T>A | 15 | COSM476 | 內源突變 |
| KRAS | p.G12D | c.35G>A | 2 | COSM521 | 3% |
| KRAS | p.Q61H | c.183A>C | 3 | COSM554 | 內源突變 |
| PIK3CA | p.E545K | c.1633G>A | 10 | COSM763 | 3% |
| PIK3CA | p.H1047R | c.3140A>G | 20 | COSM775 | 內源突變 |
| EML4-ALK | E13-A20 | DNA Translocation | N/A | COSF408 | 3% |
| CCDC6-RET | E1-E12 | DNA Translocation | N/A | COSF1271 | 3% |
| ERBB2 | CNV | Amplication | N/A | N/A | CN=4 |
| Panel-Ref™ gDNA Cocktail VI Reference Standard | |||||
| Gene | AA Change | CDS Change | Exon | Cosmic ID | Expected AF |
| BRAF | p.V600E | c.1799T>A | 15 | COSM476 | 5% |
| PIK3CA | p.H1047R | c.3140A>G | 20 | COSM775 | 5% |
| KRAS | p.G13D | c.38G>A | 2 | COSM532 | 5% |
| BRCA2 | p.I2675Dfs*6 | c.8021dup | 18 | COSM2071519 | 5% |
| Panel-Ref™ gDNA Cocktail Ⅶ Reference Standard | |||||
| Gene | AA Change | CDS Change | Exon | Cosmic ID | Expected AF |
| EGFR | p.E746_A750del | c.2236_2250del15 | 19 | COSM6225 | 5% |
| EGFR | p.S768I | c.2303G>T | 20 | COSM6241 | 5% |
| EGFR | p.L861Q | c.2582T>A | 21 | COSM6213 | 5% |
| MET | CNV | Amplification | N/A | N/A | CN=6 |
| ERBB2 | p.A775_G776insYVMA | c.2324_2325ins12 | 20 | COSM12558 | 5% |
| KRAS | p.G12V | c.35G>T | 2 | COSM520 | 5% |
| PIK3CA | p.E542K | c.1624G>A | 10 | COSM760 | 5% |
| KRAS | p.Q61H | c.183A>C | 3 | COSM554 | 5% |
| BRAF | p.V600E | c.1799T>A | 15 | COSM476 | 內源突變 |
| PIK3CA | p.H1047R | c.3140A>G | 20 | COSM775 | 內源突變 |
| EGFR | p.G719C | c.2155G>T | 18 | COSM6253 | 5% |
| CD74-ROS1 | E6-E34 | DNA Translocation | N/A | COSF1200 | 5% |
| NRAS | p.Q61K | c.181C>A | 3 | COSM580 | 5% |
| IDH1 | p.R132C | c.394C>T | 4 | COSM28747 | 5% |
| 陰性對照 | |||||
| Mutation | 0% | ||||
| Fusion | 0% | ||||
| Expected %AF | CN=2 | ||||
| Product Information | |||||
| Intended Use | Research Use Only | ||||
| Unit Size | 1ug/vial * 6 vials | ||||
| Concentration | Download for COA | ||||
| Purity | Download for COA | ||||
| DNA electrophoresis | Download for COA | ||||
| Storage | -20°C | ||||
| Expiry | 36 months from the date of manufacture | ||||
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