南京科佰生物科技有限公司官方網站歡迎您的光臨！
免費咨詢熱線： 4008-750-250
科研細胞
藥靶細胞
標準品
AI-Edigene? ABL1 p.T315I Reference Standard Plus
|
CBP10519
|
|
| Format | Genomic DNA |
| Description | ABL1 T315I is a gatekeeper mutation that lies within the hinge region of the protein kinase domain of the Abl1 protein (PMID: 18794843). T315I has been demonstrated to occur as a secondary resistance mutation and results in increased kinase activity and transformation in the context of BCR-ABL1 in cell culture (PMID: 11423618, PMID: 18794843, PMID: 27890928), and results in reduced catalytic efficiency (kcat/km) in an in vitro assay (PMID: 30684523), but has not been fully characterized and therefore, its effect on Abl1 protein function is unknown. |
| Technical Data | |
| DNA Change | c.944C>T |
| AA Change | p.T315I |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100.00% |
| Transcript | NM_007313.2 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | -20°C |
| Expiry | 36 months from the date of manufacture |
掃一掃，關注我們公眾號
Copyright ?2021 www.ventura-flowers.com All Rights Reserved. 南京科佰生物科技有限公司版權所有 蘇ICP備13038923號