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AI-Edigene? ABL1 p.T315I Reference Standard Plus
CBP10519
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Format | Genomic DNA |
Description | ABL1 T315I is a gatekeeper mutation that lies within the hinge region of the protein kinase domain of the Abl1 protein (PMID: 18794843). T315I has been demonstrated to occur as a secondary resistance mutation and results in increased kinase activity and transformation in the context of BCR-ABL1 in cell culture (PMID: 11423618, PMID: 18794843, PMID: 27890928), and results in reduced catalytic efficiency (kcat/km) in an in vitro assay (PMID: 30684523), but has not been fully characterized and therefore, its effect on Abl1 protein function is unknown. |
Technical Data | |
DNA Change | c.944C>T |
AA Change | p.T315I |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100.00% |
Transcript | NM_007313.2 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | ![]() |
Storage | -20°C |
Expiry | 36 months from the date of manufacture |

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